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HINFP

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Federation for Aging Research and 3 more
  • Animals1

Effects

2

Cellular senescence

downin human cells1

1 study

  1. HINFP inhibits cellular senescence in human cells.

    “Knockdown of HINFP, a key HLB component, in human RPE cells induced histone loss, senescence, and the upregulation of senescence-associated secretory phenotype (SASP) markers.”

    Cellsknockdown of HINFPRPE cells

    Histone deficiency and hypoacetylation in the aging retinal pigment epithelium

    Aging cell26 Feb 2024

More on Cellular senescence

Histone levels

downin human cells1

1 study

  1. HINFP decreases histone levels in human cells.

    “Knockdown of HINFP, a key HLB component, in human RPE cells induced histone loss, senescence, and the upregulation of senescence-associated secretory phenotype (SASP) markers.”

    Cellsknockdown of HINFPRPE cells

    Histone deficiency and hypoacetylation in the aging retinal pigment epithelium

    Aging cell26 Feb 2024

More on Histone levels

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