HAP4

HAP4 increases ursodeoxycholic acid whole-cell catalytic efficiency in yeast cells (44.4% catalytic efficiency; 14.8-fold increase compared with BY-RT).

“the catalytic efficiency of BY-RT-HAP4 remained at 44.4%, representing a 14.8-fold increase compared with BY-RT.”

CellsHAP4 overexpression in BY-RT-HAP4 versus BY-RT during shake-flask fermentation20 days

Construction of a long-lived engineered yeast and its efficient catalytic synthesis of ursodeoxycholic acid

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Jul 2026

HAP4 increases cell survival rate in yeast cells (4.5-fold higher survival rate than wild type).

“the survival rate of cells overexpressing HAP4 was 4.5-fold higher than that of the wild type”

CellsHAP4 overexpression under chenodeoxycholic acid stress; compared with wild type8 days of fermentation

Construction of a long-lived engineered yeast and its efficient catalytic synthesis of ursodeoxycholic acid

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·1 Jul 2026