H2AJ

H2AJ protects against fibrosis in mice.

“Unlike WT controls, KO kidneys developed progressive tubular atrophy and incipient fibrosis, indicating a failure in regenerative capacity.”

Animalsfollowing ionizing radiationkidney

Histone Variant H2A.J Links Epigenetic Reprogramming to Mitochondrial-dependent Kidney Regeneration under Radiation Stress

bioRxiv (Cold Spring Harbor Laboratory)·19 Jun 2026Preprint

H2AJ is required for tubular regeneration in mice.

“Our findings suggest that H2A.J loss impairs tubular regeneration due to defective mitochondrial activation, resulting in insufficient energy supply for coordinated repair.”

Animalsfollowing ionizing radiationkidney

Histone Variant H2A.J Links Epigenetic Reprogramming to Mitochondrial-dependent Kidney Regeneration under Radiation Stress

bioRxiv (Cold Spring Harbor Laboratory)·19 Jun 2026Preprint

H2AJ protects against tubular damage in mice.

“KO kidneys exhibited significantly more severe histopathological damage, including tubular dilation, flattened epithelium, associated with increased apoptosis, and premature senescence”

Animalsfollowing ionizing radiationkidney

Histone Variant H2A.J Links Epigenetic Reprogramming to Mitochondrial-dependent Kidney Regeneration under Radiation Stress

bioRxiv (Cold Spring Harbor Laboratory)·19 Jun 2026Preprint