grh

1. grh impairs cellular homeostasis in flies.

   “high level ectopic expression of a member of this isoform class in enteroblasts, but not ISCs, resulted in cells with confused identity and promoted excess proliferation in the epithelium”

   Model organismshigh level ectopic expression in enteroblastsmidgut epithelium

   Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation

   Cell death discovery·28 Apr 2025

More on Cellular homeostasis

1. grh increases stem cell differentiation in flies.

   “Grh.O mutant ISCs were not lost due to cell death but were forced to differentiate.”

   Model organismsspecific loss of all Grh.O isoformsmidgut epithelium

   Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation

   Cell death discovery·28 Apr 2025

More on Stem cell differentiation

1. grh decreases intestinal stem cells in flies.

   “specific loss of all Grh.O isoforms results in loss of ISCs from the epithelium”

   Model organismsGrh.O mutant clonesmidgut epithelium

   Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation

   Cell death discovery·28 Apr 2025