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GIGYF2

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Key Research and Development Projects of Shaanxi Province and 2 more
  • Cells1

Effects

2

Arterial stiffness

downin mice1

1 study

  1. GIGYF2 protects against arterial stiffness in mice.

    “In the mice model, GIGYF2flox/flox Cdh-Cre+ mice protected aged mice from aging-associated vascular endothelium-dependent relaxation and arterial stiffness.”

    Animalsendothelial-specific knockout (GIGYF2flox/flox Cdh-Cre+)aorta

    Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function

    Redox biologyJul 24, 2023

Cellular senescence

upin human cells1

1 study

  1. GIGYF2 induces cellular senescence in human cells.

    “overexpressing GIGYF2 promoted eNOS-uncoupling, cellular senescence, endothelial dysfunction, and activation of the mTORC1-SK61 pathway”

    Cellsin non-senescent human endothelial cellsendothelium

    Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function

    Redox biologyJul 24, 2023

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