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GCN5

Gene

1 paper1 finding

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Japan Agency for Medical Research and Development and 2 more
  • Cells1

Effects

1

rDNA instability

upin yeast cells1

1 study

  1. GCN5 increases rDNA instability in yeast cells.

    “Depletion of Gcn5, the enzyme responsible for H3K14 acetylation, reduced E-pro transcription and mitigated rDNA instability in old cells.”

    Cellsshown by depletion

    ERC accumulation depletes Sir2 from rDNA and induces cellular senescence by rDNA destabilization

    Nucleic acids research28 Oct 2025

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