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FRAIL1

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases and 1 more
  • Humans1

Effects

1

Muscle fiber size

downin mice1

1 study

  1. FRAIL1 decreases muscle fiber size in mice.

    “Forced expression of FRAIL1 in mouse tibialis anterior muscle elicits a dose-dependent reduction in skeletal muscle fiber size”

    Animalsforced expressiontibialis anterior muscle

    Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function

    Aging cell31 Jan 2024

Associations

1

Physical function

downin humans1

1 study

  1. FRAIL1 is associated with physical function in humans.

    “skeletal muscle FRAIL1 was increased with age in conjunction with lower muscle function.”

    Humansskeletal muscle

    Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function

    Aging cell31 Jan 2024

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