EIF5A2

1. EIF5A2 increases cell viability in human cells.

   “EIF5A2-OE promoted the viability of SH-SY5Y cells and reduced cell senescence in vitro.”

   CellsSH-SY5Y cells

   EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells

   BMC geriatrics·Feb 7, 2023

1. EIF5A2 decreases cellular senescence in human cells.

   “EIF5A2-OE promoted the viability of SH-SY5Y cells and reduced cell senescence in vitro.”

   CellsSH-SY5Y cells

   EIF5A2 specifically regulates the transcription of aging-related genes in human neuroblastoma cells

   BMC geriatrics·Feb 7, 2023

More on Cellular senescence

1. EIF5A2 decreases TP53 in mouse cells.

   “activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells.”

   Cellstransgenic mouse embryo fibroblast (MEF) cells

   Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

   BMC cancer·May 26, 2011

More on TP53

1. EIF5A2 increases aneuploidy cells in mice.

   “a significantly increase in number of aneuploidy cells (p < 0.05) resulted from an increase in the incidences of misaligned and lagging chromosomal materials”

   Animalstransgenic mice

   Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

   BMC cancer·May 26, 2011

More on Aneuploidy cells

1. EIF5A2 shortens lifespan in mice.

   “overexpression of eIF-5A2 accelerated the aging process in adult transgenic mice. This included decreased growth rate and body weight, shortened life span”

   Animalsoverexpression

   Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

   BMC cancer·May 26, 2011