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EI24

Gene

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Research Foundation and 1 more
  • Animals1

Effects

4

Diabetes mellitus

downin mice1

1 study

  1. EI24 protects against diabetes mellitus in mice.

    “Ei24 TG mice also demonstrated resistance to high-dose STZ-induced diabetes.”

    AnimalsEi24 transgenic mice exposed to high-dose streptozotocinmales

    EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice

    Frontiers in aging10 Jun 2025

More on Diabetes mellitus

Glucose uptake

upin mice1

1 study

  1. EI24 increases glucose uptake in mice.

    “Moreover, Ei24 overexpression enhanced glucose uptake, likely due to increased Glut4 expression in muscle tissue.”

    AnimalsEi24 overexpressionmales

    EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice

    Frontiers in aging10 Jun 2025

Aging markers

downin mice1

1 study

  1. EI24 decreases aging markers in mice.

    “Male Ei24 TG mice exhibited signs of healthier aging, with reduced aging markers in the kidney, liver, and pancreas.”

    AnimalsEi24 overexpression in transgenic micekidney, liver, and pancreasmales

    EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice

    Frontiers in aging10 Jun 2025

More on Aging markers

IGF1R phosphorylation

downin mice1

1 study

  1. EI24 decreases IGF1R phosphorylation in mice.

    “EI24 was found to bind to IGF1R, specifically engaging with its transmembrane (TM) domain near the cytoplasmic membrane, and suppress its phosphorylation.”

    Animals

    EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice

    Frontiers in aging10 Jun 2025

More on IGF1R phosphorylation

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