DLX5
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and 1 more
- 3 of 4 findings with company ties
- Animals2
Effects
3Healthspan
downin mice1
1 study
Healthspan
downin mice1
DLX5 impairs healthspan in mice.
“Hallmarks of biological aging such as motility, adiposity and coat conditions are improved in mutant animals.”
Animalsshown by inactivation of Dlx5 and Dlx6 in GABAergic interneurons (VgatΔDlx5-6)
Aging12 Sep 2019
Lifespan
downin mice1+33% median survival
1 study
Lifespan
downin mice1+33% median survival
DLX5 shortens lifespan in mice (+33% median survival).
“Remarkably, both VgatΔDlx5-6/+ and VgatΔDlx5-6 mice present a 33% longer median survival.”
Animalsshown by inactivation of Dlx5 and Dlx6 in GABAergic interneurons (VgatΔDlx5-6/+ and VgatΔDlx5-6)
Aging12 Sep 2019
Body weight
downin mice1−25%
1 study
Body weight
downin mice1−25%
DLX5 decreases body weight in mice (-25%).
“Twenty-month-old VgatΔDlx5-6 animals have the same size as their normal littermates, but present a 25% body weight reduction associated with a marked decline in white and brown adipose tissue.”
Animalsshown by simultaneous inactivation of Dlx5 and Dlx6 in GABAergic interneurons (VgatΔDlx5-6)
Aging12 Sep 2019
Associations
1Semi-supercentenarians
downin humans1
1 study
Semi-supercentenarians
downin humans1
DLX5 is associated with semi-supercentenarians in humans.
“The DLX5/6-N-Haplotype is significantly underrepresented in semi-supercentenarians (>105 years of age)”
Humans
DLX5/6 GABAergic Expression Affects Social Vocalization: Implications for Human Evolution
Molecular biology and evolution27 Oct 2021