There are 7 papers on dilp2 in aging research: none in people yet, 7 in animals.
At a glance
The findings reach worms or flies, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: American Federation of Aging Research and 4 more
- Model organisms7
Effects
3Germline stem cell loss
downin flies1
1 study
Germline stem cell loss
downin flies1
dilp2 decreases germline stem cell loss in flies.
“The use of lines #2305 or #2261 to overexpress Drosophila insulin-like peptide 2, which maintains GSC lifespan, in aged niche cap cells significantly delayed age-dependent GSC loss.”
Model organismsoverexpression in aged niche cap cells using GeneSwitch GAL4 lines #2305 or #2261 with RU486 inductionGeneSwitch GAL4niche cap cellsfemales
G3 (Bethesda, Md.)
Akh mRNA and protein
downin flies1
1 study
Akh mRNA and protein
downin flies1
dilp2 decreases Akh mRNA and protein in flies (shown by dilp2 mutants; dependent on dilp1).
“Mutants of dilp2 extend lifespan and increase Akh mRNA and protein in a dilp1-dependent manner.”
Model organismsshown by dilp2 mutants; dependent on dilp1
Aging cell
Lifespan
downin flies1
1 study
Lifespan
downin flies1
dilp2 shortens lifespan in flies (shown by dilp2 mutants).
“Mutants of dilp2 extend lifespan and increase Akh mRNA and protein in a dilp1-dependent manner.”
Model organismsshown by dilp2 mutants
Aging cell