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DNMT3AMISSENSEMUTATIONS

There is 1 paper on DNMT3AMISSENSEMUTATIONS in aging research: none in people yet, 1 in cells.

Gene

1 paper studies it2 findings

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Cancer Society and others
  • Cells1

Effects

2

Protein stability

downin human cells1

1 study

  1. DNMT3AMISSENSEMUTATIONS decreases protein stability in human cells (half of the variants).

    “Half of these variants exhibited reduced protein stability”

    Cells

    Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor

    Cancer discovery

Methyltransferase activity

downin human cells1

1 study

  1. DNMT3AMISSENSEMUTATIONS decreases methyltransferase activity in human cells (74% of 253 mutations).

    “found that 74% were loss-of-function mutations”

    Cells

    Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor

    Cancer discovery

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