bioRxiv
Reducing a protein shifts gene activity in human immune cells
Experiments in lab-grown brain immune cells shifted gene activity away from disease-associated states and toward inflammatory responses, with weaker responses in cells…Experiments in lab-grown brain immune cells shifted gene activity away from disease-associated states and toward inflammatory responses, with weaker responses in cells carrying an Alzheimer’s-linked gene variant.
Preprint: human cell studyMechanisms
Who was studiedHuman stem-cell-derived microglia
What changedReducing DAB2 shifted microglial gene activity away from disease-linked states and toward inflammatory responses
The catchAmyloid-beta clearance was linked to gene networks, rather than measured directly