CTAGE5
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
Effects
4Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
CTAGE5 prevents cellular senescence in mouse cells.
“This results in abnormal nuclear (envelope) morphology and cellular senescence, likely driven by activation of the P53/P21 senescence pathway.”
Cellsshown by loss of cTAGE5
Aging cell30 Jul 2025
LBR localization to the inner nuclear membrane
is required forin mouse cells1
1 study
LBR localization to the inner nuclear membrane
is required forin mouse cells1
CTAGE5 is required for LBR localization to the inner nuclear membrane in mouse cells.
“Loss of cTAGE5 disrupts LBR's localization to the inner nuclear membrane, leading to its retention in the ER and instability.”
Cellsshown by loss of cTAGE5
Aging cell30 Jul 2025
Abnormal nuclear structure
downin mouse cells1
1 study
Abnormal nuclear structure
downin mouse cells1
CTAGE5 protects against abnormal nuclear structure in mouse cells.
“cTAGE5 deficiency leads to abnormal nuclear structure and disturbed cell proliferation in MEF cells.”
Cellsshown by cTAGE5 deficiencymouse embryonic fibroblast
Aging cell30 Jul 2025
Premature aging
downin mice1
1 study
Premature aging
downin mice1
CTAGE5 protects against premature aging in mice.
“conditional cTAGE5 knockout results in embryonic lethality during development and premature aging in adult mice.”
Animalsshown by conditional cTAGE5 knockout
Aging cell30 Jul 2025