There are 2 papers on CRTC2 in aging research: none in people yet, 1 in animals, 1 in cells.
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Korea Basic Science Institute and 1 more
- Animals1
- Cells1
Effects
3Adipogenic potential
downin mice1
1 study
Adipogenic potential
downin mice1
CRTC2 decreases adipogenic potential in mice (shown by knockout, single-cell RNA sequencing).
“age-associated decline in adipogenic potential of visceral adipose tissues was reinstated by Crtc2 knockout”
Animalsshown by knockout, single-cell RNA sequencingvisceral adipose tissue
Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
Nature aging
Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
CRTC2 increases cellular senescence in mice (shown by adipocyte-specific knockout).
“which was restored by Crtc2 knockout in adipocytes”
Animalsshown by adipocyte-specific knockoutvisceral adipose tissue
Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
Nature aging
Age-associated metabolic decline
upin mice1
1 study
Age-associated metabolic decline
upin mice1
CRTC2 increases age-associated metabolic decline in mice (shown by adipocyte-specific knockout).
“We found that adipocyte-specific Crtc2 knockout protected mice from age-associated metabolic decline.”
Animalsshown by adipocyte-specific knockoutadipose tissue
Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
Nature aging