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Gene

1 paper studies it3 findings

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Baylor College of Medicine and others
  • Humans1

Effects

3

Rothmund-Thomson syndrome

upin humans1

1 study

  1. CRIPT induces Rothmund-Thomson syndrome in humans.

    “CRIPT causes an RTS-like syndrome associated with neurodevelopmental delay and epilepsy”

    Humans

    Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence

    Genetics in medicine : official journal of the American College of Medical Genetics

More on Rothmund-Thomson syndrome

Senescence-associated beta-galactosidase

upin human cells1

1 study

  1. CRIPT increases senescence-associated beta-galactosidase in human cells.

    “the senescence-associated ß-galactosidase activity was elevated in CRIPT-deficient fibroblasts”

    Cellsin CRIPT-deficient fibroblasts

    Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence

    Genetics in medicine : official journal of the American College of Medical Genetics

More on Senescence-associated beta-galactosidase

Cellular senescence

upin humans1

1 study

  1. CRIPT increases cellular senescence in humans.

    “Skin biopsies revealed a high expression of senescence markers (p53/p16/p21)”

    Humansskin

    Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence

    Genetics in medicine : official journal of the American College of Medical Genetics

More on Cellular senescence

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