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CLEC1B

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Animals1

Effects

3

Hematogenous metastasis in the lungs

downin mice1

1 study

  1. CLEC1B decreases hematogenous metastasis in the lungs in mice.

    “target activation of CLEC-1b in ECs decreased the hematogenous metastasis in the lungs by cancer cells expressing PDPN in mice”

    Animalstarget activation in endothelial cellslung

    Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis

    Biochemical and biophysical research communications22 Mar 2024

Transendothelial migration of PDPN-expressing cancer cells

downin cells1

1 study

  1. CLEC1B inhibits transendothelial migration of PDPN-expressing cancer cells in cells.

    “inhibited the transendothelial migration of cancer cells expressing podoplanin (PDPN), a ligand for CLEC-1b”

    Cellsoverexpression in endothelial cellsendothelial cells

    Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis

    Biochemical and biophysical research communications22 Mar 2024

Disruption of endothelial integrity

downin cells1

1 study

  1. CLEC1B prevents disruption of endothelial integrity in cells.

    “CLEC-1b overexpression in ECs prevented the disruption of endothelial integrity”

    Cellsoverexpression in endothelial cellsendothelial cells

    Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis

    Biochemical and biophysical research communications22 Mar 2024

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