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Cisd

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Eusko Jaurlaritza and 7 more
  • Model organisms1

Effects

2

Lifespan

downin flies1

1 study

  1. Cisd shortens lifespan in flies.

    “reduction of Cisd levels upregulates mitophagy in vitro and in vivo, and ameliorates pathological phenotypes in locomotion, lifespan and neurodegeneration in Pink1/parkin mutant flies.”

    Model organismsin Pink1/parkin mutant flies

    Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

    Molecular neurodegeneration25 Jan 2024

Mitophagy

downin flies1

1 study

  1. Cisd inhibits mitophagy in flies.

    “Age-related increase of Cisd blocks mitophagy and impairs autophagy flux.”

    Model organismsin Pink1 and parkin mutant flies and during ageing

    Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

    Molecular neurodegeneration25 Jan 2024

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