What does the research say about CHKA?

CHKA

There are 2 papers on CHKA in aging research: 1 observational study in people, 1 in animals. The newest story, Oct 28, 2026: “Enzyme inhibition curbed mutant blood cell expansion in zebrafish”.

Gene

2 papers study it7 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 2 papers on CHKA

At a glance

The findings reach people, from one lab or study. 2 independent labs in 2 countries.

None of its findings points the other way.

2 independent labs in 2 countries

Funders: Fundamental Research Funds for the Central Universities and 3 more

Humans1
Animals1

Effects

Clonal expansion

upin human cells1upin mice1upin zebrafish1

1 study

CHKA increases clonal expansion in human cells (TET2 model; shown by suppression of CHKA-dependent choline flux).
“This effect was conserved in a murine DNMT3A and human TET2 model.”
CellsTET2 model; shown by suppression of CHKA-dependent choline flux
Enzyme inhibition curbed mutant blood cell expansion in zebrafish
bioRxivOct 28, 2026Preprint
CHKA increases clonal expansion in mice (DNMT3A model; shown by suppression of CHKA-dependent choline flux).
“This effect was conserved in a murine DNMT3A and human TET2 model.”
AnimalsDNMT3A model; shown by suppression of CHKA-dependent choline flux
Enzyme inhibition curbed mutant blood cell expansion in zebrafish
bioRxivOct 28, 2026Preprint
CHKA increases clonal expansion in zebrafish (ASXL1-mutant model; shown by suppression of CHKA-dependent choline flux).
“Suppressing CHKA-dependent choline flux reduced ASXL1-driven clonal expansion.”
AnimalsASXL1-mutant model; shown by suppression of CHKA-dependent choline fluxhematopoietic stem and progenitor cell
Enzyme inhibition curbed mutant blood cell expansion in zebrafish
bioRxivOct 28, 2026Preprint

NAD+

upin cells1

1 study

CHKA increases NAD+ in cells (shown by CHKA silencing).
“CHKA silencing also disrupted NAD+ metabolism, causing reduced NAD+ levels.”
Cellsshown by CHKA silencing
Metabolic Stress-Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes-Associated Microvascular Dysfunction
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Jun 23, 2025

Associations

Diabetic microvascular complications

upin humans1

1 study

CHKA is associated with diabetic microvascular complications in humans (increased expression; clinical samples and Mendelian randomization).
“Clinical sample analysis and Mendelian randomization studies provided strong evidence linking increased CHKA expression with diabetic microvascular complications.”
Humansincreased expression; clinical samples and Mendelian randomization
Metabolic Stress-Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes-Associated Microvascular Dysfunction
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Jun 23, 2025

More on Diabetic microvascular complications

Latest

1 paper in 12 months

bioRxivOct 28

Enzyme inhibition curbed mutant blood cell expansion in zebrafish

Experiments in zebrafish targeted an enzyme involved in processing choline, a nutrient, and reduced expansion of blood-forming cells carrying a mutation.Experiments in zebrafish targeted an enzyme involved in processing choline, a nutrient, and reduced expansion of blood-forming cells carrying a mutation.

Preprint: fish studyMechanisms