bioRxiv
Enzyme inhibition curbed mutant blood cell expansion in zebrafish
Experiments in zebrafish targeted an enzyme involved in processing choline, a nutrient, and reduced expansion of blood-forming cells carrying a mutation.Experiments in zebrafish targeted an enzyme involved in processing choline, a nutrient, and reduced expansion of blood-forming cells carrying a mutation.
Preprint: fish studyMechanisms
Who was studiedZebrafish with asxl1-mutant blood-forming cells
What changedBlocking choline kinase alpha reduced expansion of mutant blood-forming cells in zebrafish
The catchMutant-cell expansion is a surrogate for blood cancer, cardiovascular disease, and survival outcomes