CFB

There are 9 papers on CFB in aging research: 3 observational studies in people, 4 in animals, 2 in cells.

9 papers study it3 findings

HGNC NCBI Gene Taxon

See all 9 papers on CFB

At a glance

The findings reach mice, none yet in people. 2 independent labs in 3 countries; 19 trials, 1 with no results posted.

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

2 independent labs in 3 countries
19 trials, 1 with no results posted

Funder: Novartis
1 of 2 findings with company ties
19 of 19 trials sponsored by developers of drugs aimed at it

Humans3
Animals4
Cells2

Effects

1

Inflammation

upin mice1

1 study

CFB increases inflammation in female Efemp1ki/ki mice.
“Deletion of the Cfb gene in female Efemp1ki/ki mice partially normalized the above dysregulated biological pathway changes”
Animalsin female Efemp1ki/ki micefemales
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration
Human molecular geneticsAug 10, 2022

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Upstream

1

Rheumatoid arthritis

upin human cells1

1 study

Rheumatoid arthritis increases CFB in RA-related cell samples.
“The RT-qPCR analysis provided preliminary mRNA-level support for the increased expression of RCAN1, IRF1, and CFB in the RA-related cell samples.”
Cellsin RA-related cell samples
Integrated Bulk and Single-Cell Transcriptomic Analysis Identifies a Reproducible SASP-Related Three-Gene Panel and Prioritizes CFB as a Fibroblast-Associated Marker in Rheumatoid Arthritis
GenesJun 26, 2026

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Associations

1

SASP-related transcriptional score

upin silico1

1 study

CFB is associated with SASP-related transcriptional score in RA single-nucleus dataset.
“CFB showed the strongest fibroblast-associated expression pattern and SASP-score correlation.”
In silicoin RA single-nucleus dataset
Integrated Bulk and Single-Cell Transcriptomic Analysis Identifies a Reproducible SASP-Related Three-Gene Panel and Prioritizes CFB as a Fibroblast-Associated Marker in Rheumatoid Arthritis
GenesJun 26, 2026

More on SASP-related transcriptional score

Latest

3 papers in 12 months

GenesJul 28

Integrated Bulk and Single-Cell Transcriptomic Analysis Identifies a Reproducible SASP-Related Three-Gene Panel and Prioritizes CFB as a Fibroblast-Associated Marker in Rheumatoid Arthritis

Experiments in cellsRheumatoid arthritis

medRxivFeb 6

Proteomic biomarkers of cognitive function, APOE ε4 status, and dementia in Generation Scotland

Preprint: cohort study of 14,745 peopleDementia

International Journal of Molecular SciencesJan 28

Complement Activation as a Predictor of Postoperative Delirium in Elderly Spine Surgery Patients

Cohort study of 22 peoplePostoperative delirium

Ophthalmology ScienceDec 20

Relationships between Lipid-Related Metabolites and Age-Related Macular Degeneration Vary with Complement Genotype

Cross-sectional study of 6,947 peopleAge-related macular degeneration

Human Molecular GeneticsAug 10

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

Experiments in miceComplement system

Research SquareApr 1

Complement Factor H-Related 3 induces inflammation and complosome activation in human RPE cells

Preprint: experiments in human cellsComplement system

BiologySep 26

Complement in Reproductive White Adipose Tissue Characterizes the Obese Preeclamptic-Like BPH/5 Mouse Prior to and During Pregnancy

Experiments in micePreeclampsia

Frontiers in Aging NeuroscienceMar 3

The Complement System Is Critical in Maintaining Retinal Integrity during Aging

Experiments in miceComplement system

Molecular & Cellular ProteomicsMar 23

Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue

Experiments in 24 miceMechanisms