casp

1. casp inhibits NF-κB signaling in flies.

   “Caspar's ability to negatively regulate NFκB signalling is not dependent on the VAPB:Caspar interaction”

   Model organisms

   Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease

   Human molecular genetics·Apr 5, 2022

More on NF-κB signaling

1. casp decreases inflammation in flies.

   “Caspar overexpression in the glia extends lifespan and also slows the progression of motor dysfunction in the ALS8 disease model, a phenomenon that we ascribe to its ability to restrain age-dependent inflammation”

   Model organismsin Drosophila gliaglia

   Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease

   Human molecular genetics·Apr 5, 2022

More on Inflammation

1. casp decreases motor dysfunction in flies.

   “Caspar overexpression in the glia extends lifespan and also slows the progression of motor dysfunction in the ALS8 disease model”

   Model organismsin the ALS8 disease modelglia

   Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease

   Human molecular genetics·Apr 5, 2022

1. casp extends lifespan in flies.

   “Caspar overexpression in the glia extends lifespan and also slows the progression of motor dysfunction in the ALS8 disease model”

   Model organismsin the ALS8 disease modelglia

   Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease

   Human molecular genetics·Apr 5, 2022