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BVR-A

There is 1 paper on BVR-A in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it2 findings

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Johns Hopkins University and 4 more
  • Animals1

Effects

2

Autophagy

is required forin mice1

1 study

  1. BVR-A is required for autophagy in mice (shown by knockout (BVR-A−/− mice)).

    “mTOR hyper-activation is associated with the impairment of autophagy as highlighted by reduced levels of Beclin-1, LC3, LC3II/I ratio, Atg5-Atg12 complex and Atg7 in the cortex of BVR-A−/− mice.”

    Animalsshown by knockout (BVR-A−/− mice)cerebral cortex

    BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration

    Antioxidants (Basel, Switzerland)

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MTOR

downin mice1

1 study

  1. BVR-A inhibits MTOR in mice (shown by knockout (BVR-A−/− mice)).

    “BVR-A deficiency leads to the accumulation of oxidatively-damaged proteins along with mTOR hyper-activation in the cortex.”

    Animalsshown by knockout (BVR-A−/− mice)cerebral cortex

    BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration

    Antioxidants (Basel, Switzerland)

More on MTOR

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