atf7

1. atf7 increases histone modification and chromatin remodelling in mice.

   “histone H3K9me2 levels on the p16Ink4a gene promoter were lower in Atf7-/- mice than in WT animals.”

   Animalson the p16Ink4a gene promoter

   Stress-induced and ATF7-dependent epigenetic change influences cellular senescence

   Genes to cells : devoted to molecular & cellular mechanisms·Jul 30, 2019

More on Histone modification and chromatin remodelling

1. atf7 decreases CDKN2A in mice.

   “Levels of p16Ink4a Cdk inhibitor mRNA increased with age more rapidly in Atf7-/- mice than in WT animals.”

   Animalswith age

   Stress-induced and ATF7-dependent epigenetic change influences cellular senescence

   Genes to cells : devoted to molecular & cellular mechanisms·Jul 30, 2019

More on CDKN2A

1. atf7 extends lifespan in mice.

   “Atf7-deficient (Atf7-/- ) mice have a shorter lifespan than wild-type (WT) mice.”

   AnimalsAtf7-deficient (Atf7-/-) vs WT

   Stress-induced and ATF7-dependent epigenetic change influences cellular senescence

   Genes to cells : devoted to molecular & cellular mechanisms·Jul 30, 2019

1. MAPK14 activates atf7 in mouse cells.

   “Phosphorylation of ATF7 by p38 was also increased with the passage of MEFs”

   CellsMEFs passage

   Stress-induced and ATF7-dependent epigenetic change influences cellular senescence

   Genes to cells : devoted to molecular & cellular mechanisms·Jul 30, 2019

More on MAPK14