aprt

1. aprt activates AMPK signalling in killifish cells.

   “heterozygous cells exhibit enhanced nutrient sensitivity, reduced ATP levels, and AMPK activation.”

   Cellsheterozygous mutation

   Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate

   Developmental cell·14 Jun 2023

More on AMPK signalling

1. aprt protects against high-fat diet in killifish.

   “metabolic functions are rejuvenated in old mutants, which also display a fasting-like metabolic profile and resistance to high-fat diet.”

   Animalsheterozygous mutation

   Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate

   Developmental cell·14 Jun 2023

More on High-fat diet

1. aprt extends lifespan in killifish.

   “we mutate APRT, a key enzyme in AMP biosynthesis, and extend the lifespan of heterozygous males.”

   Animalsheterozygous mutationmales

   Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate

   Developmental cell·14 Jun 2023