appa

1. appa impairs learning capacity in killifish.

   “The lack of appa mitigated brain aging from a proteome-wide perspective, reduced age-related cell death and inflammation, and improved neuronal activity and learning capacity in aged individuals.”

   Animalsshown by appa knockout during spontaneous brain aging

   Amyloid-beta precursor protein contributes to brain aging and learning decline

   bioRxiv (Cold Spring Harbor Laboratory)·12 Oct 2024Preprint

1. appa impairs neuronal activity in killifish.

   “The lack of appa mitigated brain aging from a proteome-wide perspective, reduced age-related cell death and inflammation, and improved neuronal activity and learning capacity in aged individuals.”

   Animalsshown by appa knockout during spontaneous brain agingbrain neuron

   Amyloid-beta precursor protein contributes to brain aging and learning decline

   bioRxiv (Cold Spring Harbor Laboratory)·12 Oct 2024Preprint

1. appa increases inflammation in killifish.

   “The lack of appa mitigated brain aging from a proteome-wide perspective, reduced age-related cell death and inflammation”

   Animalsshown by appa knockout during spontaneous brain agingbrain

   Amyloid-beta precursor protein contributes to brain aging and learning decline

   bioRxiv (Cold Spring Harbor Laboratory)·12 Oct 2024Preprint

More on Inflammation

1. appa increases age-related cell death in killifish.

   “The lack of appa mitigated brain aging from a proteome-wide perspective, reduced age-related cell death and inflammation”

   Animalsshown by appa knockout during spontaneous brain agingbrain

   Amyloid-beta precursor protein contributes to brain aging and learning decline

   bioRxiv (Cold Spring Harbor Laboratory)·12 Oct 2024Preprint