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ALDH2RS671GA/AA

There is 1 paper on ALDH2RS671GA/AA in aging research: 1 observational study in people. The newest story, Oct 27, 2026: “Combinations of gene variants linked to four cancer types”.

Gene

1 paper studies it3 findings

1 new paper in 30 daysSee all 1

“HRR PGV carriers with the rs671 GA/AA genotype showed increased risk across all cancer sites compared with rs671 GG non-carriers.”
Joint Effects of ALDH2 rs671 and Pathogenic Germline Variants in DNA Repair Genes on Risk of Aerodigestive and Gastrointestinal CancersCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026doi:10.1158/1055-9965.epi-26-0629

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab
  • Humans1

Associations

3

Colorectal cancer risk

upin humans1OR 24.57

1 study

  1. ALDH2RS671GA/AA is associated with colorectal cancer risk in humans (MMR pathogenic germline variant carriers; elevated risk in drinkers and non-drinkers) (OR 24.57; interaction P = 0.0011).

    “Among MMR PGV carriers, rs671 GA/AA was associated with increased risk of esophageal and colorectal cancers (odds ratio, 95.62 and 24.57, respectively)”

    HumansMMR pathogenic germline variant carriers; elevated risk in drinkers and non-drinkers

    Combinations of gene variants linked to four cancer types

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

More on Colorectal cancer risk

Esophageal cancer risk

upin humans1

1 study

  1. ALDH2RS671GA/AA is associated with esophageal cancer risk in humans (MMR pathogenic germline variant carriers) (OR 95.62; interaction P = 0.017).

    “Among MMR PGV carriers, rs671 GA/AA was associated with increased risk of esophageal and colorectal cancers (odds ratio, 95.62 and 24.57, respectively)”

    HumansMMR pathogenic germline variant carriers

    Combinations of gene variants linked to four cancer types

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

More on Esophageal cancer risk

Head and neck, esophageal, gastric, and colorectal cancer risk

upin humans1

1 study

  1. ALDH2RS671GA/AA is associated with head and neck, esophageal, gastric, and colorectal cancer risk in humans.

    “HRR PGV carriers with the rs671 GA/AA genotype showed increased risk across all cancer sites compared with rs671 GG non-carriers.”

    HumansHRR pathogenic germline variant carriers with ALDH2 rs671 GA/AA versus rs671 GG non-carriers

    Combinations of gene variants linked to four cancer types

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

More on Head and neck, esophageal, gastric, and colorectal cancer risk

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 paper in 12 months
Cancer Epidemiology, Biomarkers & Prevention

Combinations of gene variants linked to four cancer types

The case-control study compared 4,418 people with cancer and 11,811 controls, finding links that differed by cancer site and alcohol intake.The case-control study compared 4,418 people with cancer and 11,811 controls, finding links that differed by cancer site and alcohol intake.

Case-control studyPopulations
Paper

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