What does the research say about Colorectal cancer risk?

Colorectal cancer risk

There is 1 paper on colorectal cancer risk in aging research: 1 observational study in people. The newest story, Oct 27, 2026: “Combinations of gene variants linked to four cancer types”.

Disease

1 paper studies it96 more mention it1 finding

10 new papers in 30 daysSee all 97

“Among MMR PGV carriers, rs671 GA/AA was associated with increased risk of esophageal and colorectal cancers (odds ratio, 95.62 and 24.57, respectively)”

Joint Effects of ALDH2 rs671 and Pathogenic Germline Variants in DNA Repair Genes on Risk of Aerodigestive and Gastrointestinal CancersCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026doi:10.1158/1055-9965.epi-26-0629

Humans1

Associations

ALDH2RS671GA/AA

upin humans1OR 24.57

1 study

ALDH2RS671GA/AA is associated with colorectal cancer risk in humans (MMR pathogenic germline variant carriers; elevated risk in drinkers and non-drinkers) (OR 24.57; interaction P = 0.0011).
“Among MMR PGV carriers, rs671 GA/AA was associated with increased risk of esophageal and colorectal cancers (odds ratio, 95.62 and 24.57, respectively)”
HumansMMR pathogenic germline variant carriers; elevated risk in drinkers and non-drinkers
Combinations of gene variants linked to four cancer types
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyOct 27, 2026

Latest

36 papers in 12 months

Cancer Epidemiology, Biomarkers & PreventionOct 27

Combinations of gene variants linked to four cancer types

The case-control study compared 4,418 people with cancer and 11,811 controls, finding links that differed by cancer site and alcohol intake.The case-control study compared 4,418 people with cancer and 11,811 controls, finding links that differed by cancer site and alcohol intake.

Case-control studyPopulations

Paper

CarcinogenesisOct 30

Exercise preconditioning mitigates colon carcinogenesis through targeted epigenetic remodeling and suppression of early preneoplastic lesions

Experiments in animalsInterventions

Paper

medRxivOct 28

Blood traces in negative stool tests link to bowel cancer risk

Two-year bowel cancer risk was 504.5 per 100,000 episodes for stool hemoglobin of 15 to under 20 micrograms per gram against 35.7 for 0 to 5.Two-year bowel cancer risk was 504.5 per 100,000 episodes for stool hemoglobin of 15 to under 20 micrograms per gram against 35.7 for 0 to 5.

Preprint: cohort · 700,734 peopleBiomarkers