ADH5

5 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Animals4
Cells1

Effects

Cognitive function

upin mice2

2 studies

ADH5 improves cognitive function in mice.
“BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition.”
Animalsshown by BAT ADH5 deletion during aging
Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife3 Oct 2025Preprint
ADH5 improves cognitive function in mice.
“BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition.”
Animalsshown by BAT ADH5 deletion during aging
Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife3 Oct 2025Preprint

Metabolic homeostasis

upin mice2

2 studies

ADH5 improves metabolic homeostasis in mice.
“BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition.”
Animalsshown by BAT ADH5 deletion during aging
Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife3 Oct 2025Preprint
ADH5 improves metabolic homeostasis in mice.
“BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition.”
Animalsshown by BAT ADH5 deletion during agingbrown adipose tissue
Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife3 Oct 2025Preprint

brown adipose tissue senescence

downin mice1

1 study

ADH5 decreases brown adipose tissue senescence in mice.
“BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition.”
Animalsshown by BAT ADH5 deletion during agingbrown adipose tissue
Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife3 Oct 2025Preprint

Cellular senescence

downin mice1

1 study

ADH5 decreases cellular senescence in mice.
“BAT ADH5-deletion accelerates BAT senescence and aging-associated declines in metabolic homeostasis and cognition.”
Animalsshown by BAT ADH5 deletionbrown adipose tissue
Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
eLife3 Oct 2025Preprint