UCHL1C152AMUTATION

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Animals1

Effects

Cognitive function

upin mice1

1 study

UCHL1C152AMUTATION improves cognitive function in mice.
“improved performance on both sensorimotor and cognitive tests compared to WT mice in both young and 18-month-old groups.”
AnimalsUchl1 C152A mutation versus wild-type controls in the asymmetric bilateral common carotid artery stenosis model
A protein mutation curbs brain damage in mice with dementia
Scientific reports7 Oct 2026

Sensorimotor function

upin mice1

1 study

UCHL1C152AMUTATION improves sensorimotor function in mice.
“improved performance on both sensorimotor and cognitive tests compared to WT mice in both young and 18-month-old groups.”
AnimalsUchl1 C152A mutation versus wild-type controls in the asymmetric bilateral common carotid artery stenosis model
A protein mutation curbs brain damage in mice with dementia
Scientific reports7 Oct 2026

White matter injury

downin mice1

1 study

UCHL1C152AMUTATION decreases white matter injury in mice.
“C152A mice exhibited reduced white matter injury as detected by DTI”
AnimalsUchl1 C152A mutation versus wild-type controls in the asymmetric bilateral common carotid artery stenosis modelwhite matter
A protein mutation curbs brain damage in mice with dementia
Scientific reports7 Oct 2026

Latest

1 in 12 months

Scientific Reports9 Oct

A protein mutation curbs brain damage in mice with dementia

Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.

Experiments in miceMechanisms

Paper

UCHL1C152AMUTATION

Effects

Latest

A protein mutation curbs brain damage in mice with dementia

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