UCHL1
Gene1 paper3 findingsHGNC 12513NCBI Gene 7345Taxon 9606
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
- Animals1
Effects
3Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
UCHL1 improves cognitive function in mice.
AnimalsC152A mutation compared with wild-type controls in the asymmetric bilateral common carotid artery stenosis model
A protein mutation curbs brain damage in mice with dementia · Scientific reports · 7 Oct 2026
Sensorimotor function
upin mice1
1 study
Sensorimotor function
upin mice1
UCHL1 improves sensorimotor function in mice.
AnimalsC152A mutation compared with wild-type controls in the asymmetric bilateral common carotid artery stenosis model
A protein mutation curbs brain damage in mice with dementia · Scientific reports · 7 Oct 2026
White matter injury
downin mice1
1 study
White matter injury
downin mice1
UCHL1 decreases white matter injury in mice.
AnimalsC152A mutation compared with wild-type controls in the asymmetric bilateral common carotid artery stenosis modelwhite matter
A protein mutation curbs brain damage in mice with dementia · Scientific reports · 7 Oct 2026
Latest
1A protein mutation curbs brain damage in mice with dementia
Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a…Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.