Venous thromboembolic disease

1. Venous thromboembolic disease increases oxidative stress and ROS signaling in human cells.

   “As compared with controls, ECFC-ECs from individuals with VTD have higher oxidative stress”

   Cellsendothelial colony-forming cells

   Reduced proliferation of endothelial colony-forming cells in unprovoked venous thromboembolic disease as a consequence of endothelial dysfunction

   PloS one·Sep 14, 2017

More on Oxidative stress and ROS signaling

1. Venous thromboembolic disease increases cellular senescence in human cells (30±1.05% vs. 91.3±15.07%).

   “in passages 4 and 10, a highly senescent rate (30±1.05% vs. 91.3±15.07%, respectively) with an increase of ROS”

   Cellsin passages 4 and 10endothelial colony-forming cells

   Reduced proliferation of endothelial colony-forming cells in unprovoked venous thromboembolic disease as a consequence of endothelial dysfunction

   PloS one·Sep 14, 2017

More on Cellular senescence

1. Venous thromboembolic disease decreases proliferation in human cells (reduced proliferation at long term (39%)).

   “Compared with cells from controls, cells from VTD patients showed an 8-fold increase of ECFCs that emerged 1 week earlier, reduced proliferation at long term (39%)”

   Cellscompared with cells from controlsendothelial colony-forming cells

   Reduced proliferation of endothelial colony-forming cells in unprovoked venous thromboembolic disease as a consequence of endothelial dysfunction

   PloS one·Sep 14, 2017