What does the research say about Synaptopathy?

Synaptopathy

There are 4 papers on synaptopathy in aging research: none in people yet, 3 in animals, 1 review. The newest story, Oct 30, 2026: “Hearing responses and speech perception diverged with age”.

Disease

4 papers study it52 more mention it2 findings

1 new paper in 30 daysSee all 56

Animals3

Interventions

Genetic reprogramming of ib/ic neurons to a ia-like identity

downin mice1

1 study

Genetic reprogramming of ib/ic neurons to a ia-like identity protects against synaptopathy in mice (noise-induced synaptopathy).
“Genetic reprogramming of Ib/Ic neurons to a Ia-like identity provided significant protection against noise-induced synaptopathy”
Animalsnoise-induced synaptopathy
Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice
Research squareSep 1, 2025Preprint

More on Genetic reprogramming of ib/ic neurons to a ia-like identity

Genetic reprogramming

downin mice1

1 study

Genetic reprogramming protects against synaptopathy in mice (noise-induced synaptopathy).
“Genetic reprogramming of Ib/Ic neurons to a Ia-like identity provided significant protection against noise-induced synaptopathy”
Animalsnoise-induced synaptopathyIb/Ic spiral ganglion neuron
Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice
bioRxiv : the preprint server for biologySep 1, 2025Preprint

Funding

10 grants since 2017

National Institute on Deafness and Other Communication Disorders$13.9MJapan Society for the Promotion of Science¥50.7MNational Institute on Aging$556K

Latest

15 papers in 12 months

Research SquareSep 15

Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice

Preprint: experiments in miceMechanisms

Paper

bioRxivSep 15

Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice

Preprint: experiments in miceMechanisms

Paper

CIENCIAMATRIAOct 21

Noise-induced sensorineural hearing loss: a silent and preventable epidemic

Systematic reviewEar

Paper

bioRxivAug 1

AAV-mediated age- and circuit-dependent restoration of photoreceptor synaptic structure and function in α2δ4-associated retinal synaptopathy

Preprint: experiments in miceEye

Paper

IECCMEXICOJul 30

Beyond the Audiogram: Current Evidence on Hidden Hearing Loss, Cochlear Synaptopathy, and Emerging Diagnostic Strategies

ReviewEar

Paper

NeuroscienceJul 29

Auditory brainstem response in the identification of cochlear synaptopathy in aged rodents: a systematic review with meta-analysis

Meta-analysis of animal and cell studiesAuditory brainstem response

Paper

Hearing ResearchJul 20

Hearing responses and speech perception diverged with age

In an observational study of adults, electrical responses to high-frequency sounds were reduced without a matching loss in speech-sound discrimination.In an observational study of adults, electrical responses to high-frequency sounds were reduced without a matching loss in speech-sound discrimination.

Cross-sectional studyEar

Paper

Nature CommunicationsJul 11

Noise and aging affect hearing nerve types differently in mice

Experiments comparing five young and seven old mice found that one hearing nerve subtype’s connections were most resilient to age-related loss.Experiments comparing five young and seven old mice found that one hearing nerve subtype’s connections were most resilient to age-related loss.

Mouse studyEar