Genetic reprogramming

Genetic reprogramming has been studied in 2 papers since 2025: none in people yet, 2 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 30, 2026: “Noise and aging affect hearing nerve types differently in mice”.

Intervention

2 papers study it2 findingsUpdated Jul 10, 2026

See all 2

None of its findings points the other way.

1 lab in 1 country

Funders: National Institute on Aging and 3 more

Animals2

What did studies of Genetic reprogramming find?

Studies of Genetic reprogramming measured 2 outcomes; the most studied are noise-induced synaptopathy (1 study) and synaptopathy (1).

noise-induced synaptopathy

downin mice1

1 study

Genetic reprogramming protects against noise-induced synaptopathy in Ib/Ic neurons.
“Genetic reprogramming of Ib/Ic neurons to a Ia-like identity provides significant protection against noise-induced synaptopathy”
Animalsin Ib/Ic neurons
Noise and aging affect hearing nerve types differently in mice
Nature communicationsJul 10, 2026

Synaptopathy

downin mice1

1 study

Genetic reprogramming protects against synaptopathy in mice (noise-induced synaptopathy).
“Genetic reprogramming of Ib/Ic neurons to a Ia-like identity provided significant protection against noise-induced synaptopathy”
Animalsnoise-induced synaptopathyIb/Ic spiral ganglion neuron
Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice
bioRxiv : the preprint server for biologySep 1, 2025Preprint

Latest

1 paper in 12 months

Nature CommunicationsJul 11

Noise and aging affect hearing nerve types differently in mice

Experiments comparing five young and seven old mice found that one hearing nerve subtype’s connections were most resilient to age-related loss.Experiments comparing five young and seven old mice found that one hearing nerve subtype’s connections were most resilient to age-related loss.

Mouse studyEar

Paper

bioRxivSep 15

Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice

Preprint: experiments in miceMechanisms