Streptococcus pneumoniae infection
4 papers study it4 more mention it1 finding
- Animals3
Associations
1Alveolar macrophage
upin mice1
1 study
Alveolar macrophage
upin mice1
Alveolar macrophage raises the risk of Streptococcus pneumoniae infection in mice.
“inherent age-related defects in AM were sufficient to increase the susceptibility to Streptococcus pneumoniae”
Animalsadoptive transfer into young micealveolar macrophages
Aging cell
Trial sponsors
Company1 trialPhase 1280 people
Funding
2 grants since 2018National Institute on AgingUS$3m
National Institute on AgingWeill Medical Coll of Cornell UnivUS$372.9k2018–2024
National Institute on AgingState University of New York at BuffaloUS$198.2k2019–2022
Latest
Cell Reports
Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice
Experiments in miceMechanisms
Nature Communications
NAD⁺ metabolism is a key modulator of bacterial respiratory epithelial infections
Experiments in rodentsNAD+ metabolism
Frontiers in Aging
Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae
Experiments in miceMetformin
Scientific Reports
Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone
Experiments in animalsInterventions
Experimental Gerontology
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection
Experiments in animalsMechanisms
American Journal of Physiology Lung Cellular and Molecular Physiology
NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection
Experiments in animalsMechanisms