Skeletal muscle hypothyroidism

Disease

1 paper2 findings

Effects

1

Muscle functionality

downin humans1

1 study
  1. Skeletal muscle hypothyroidism impairs muscle functionality in humans.

    “underlying a role of skeletal muscle hypothyroidism in adaptive thermogenesis driving catch-up fat, but which can also concomitantly compromise muscle functionality”

    Reviewskeletal muscle

    Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity

    Reviews in endocrine & metabolic disorders26 May 2025

Upstream

1

DIO3

upin humans1

1 study
  1. DIO3 induces skeletal muscle hypothyroidism in humans.

    “Emerging evidence linking it to an upregulation of skeletal muscle type 3 deiodinase (D3), the main thyroid hormone inactivating enzyme”

    Reviewskeletal muscle

    Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity

    Reviews in endocrine & metabolic disorders26 May 2025

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