There are 4 papers on progression to diabetes in aging research: 3 observational studies in people, 1 review.
4 papers study it179 more mention it6 findings
8 new papers in 30 daysSee all 183 papers on progression to diabetes
“Baseline low uPH (<6.0) was independently associated with a significantly increased risk of progression (HR 3.15, 95% CI 2.33 to 4.25, p<0.001)”
- Humans3
Associations
6Urine pH
upin humans1HR 3.15
1 study
Urine pH
upin humans1HR 3.15
Urine pH is associated with progression to diabetes in humans (Prediabetes; baseline urine pH <6.0 compared with ≥6.5) (HR 3.15, 95% CI 2.33–4.25).
“Baseline low uPH (<6.0) was independently associated with a significantly increased risk of progression (HR 3.15, 95% CI 2.33 to 4.25, p<0.001)”
HumansPrediabetes; baseline urine pH <6.0 compared with ≥6.5Median follow-up of 1.95 yearsn = 6,165
BMJ open
Cumulative LCI-CRP
upin humans1HR 2.18
1 study
Cumulative LCI-CRP
upin humans1HR 2.18
Cumulative LCI-CRP is associated with progression to diabetes in humans (baseline prediabetes) (HR 2.18, 95% CI 1.63–2.91).
“participants with highest tertile of cumulative AIP-CRP and LCI-CRP had more than double the risk of progression to diabetes”
Humansbaseline prediabeteshighest tertile3 yearsn = 2,544
ESC Congress 2026 abstract
Cumulative AIP-CRP
upin humans1HR 2.17
1 study
Cumulative AIP-CRP
upin humans1HR 2.17
Cumulative AIP-CRP is associated with progression to diabetes in humans (baseline prediabetes) (HR 2.17, 95% CI 1.63–2.90).
“participants with highest tertile of cumulative AIP-CRP and LCI-CRP had more than double the risk of progression to diabetes”
Humansbaseline prediabeteshighest tertile3 yearsn = 2,544
ESC Congress 2026 abstract
Cumulative non-traditional lipid parameters
upin humans1
1 study
Cumulative non-traditional lipid parameters
upin humans1
Cumulative non-traditional lipid parameters are associated with progression to diabetes in humans (baseline prediabetes) (HR range: 1.14–1.26).
“Cumulative exposures to non-traditional lipid parameters were independently associated with progression to diabetes (HR range: 1.14-1.26, P<0.05)”
Humansbaseline prediabetes3 yearsn = 2,544
ESC Congress 2026 abstract
METS-IR–body shape products
upin humans1
1 study
METS-IR–body shape products
upin humans1
METS-IR–body shape products are associated with progression to diabetes in humans (Chinese adults with baseline prediabetes; maintained prediabetes as the reference) (ORs per standard deviation 1.46–1.53; standardized progression probability differences 14.8–17.1 percentage points).
“All four baseline products were associated with higher progression odds, with odds ratios per standard deviation ranging from 1.46 to 1.53”
HumansChinese adults with baseline prediabetes; maintained prediabetes as the reference2011–2012 to 2015n = 2,116
Research SquarePreprint
Semaglutide
downin humans1
1 study
Semaglutide
downin humans1
Semaglutide lowers the risk of progression to diabetes in humans (prediabetes; compared with placebo).
“semaglutide 2.4 mg significantly increased regression to normoglycemia (up to 84 %) and reduced the risk of progression to diabetes compared with placebo.”
Reviewprediabetes; compared with placebo2.4 mg
Primary care diabetes