1 paper
National Institute of Allergy and Infectious Diseases
1 trialPhase 282 people
In 6,104 older adults, each 5-point rise in depressive symptoms carried an odds ratio for hospital admission of 1.25 in frail people versus 1.00 in robust peers.In 6,104 older adults, each 5-point rise in depressive symptoms carried an odds ratio for hospital admission of 1.25 in frail people versus 1.00 in robust peers.
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.
In prefrail and frail adults, top-quartile cardiorespiratory fitness was tied to lower odds of cognitive impairment (OR 0.15) versus the lowest quartile.In prefrail and frail adults, top-quartile cardiorespiratory fitness was tied to lower odds of cognitive impairment (OR 0.15) versus the lowest quartile.
Frailty category improved in 69.6% of high-intensity walkers compared with 46.4% of casual-speed walkers over a 16-week intervention.Frailty category improved in 69.6% of high-intensity walkers compared with 46.4% of casual-speed walkers over a 16-week intervention.
Global cognitive aging rates showed an inverted U-shaped link with systolic pressure, peaking at 120.1 mmHg overall and 130.8 mmHg in prefrail older adults.Global cognitive aging rates showed an inverted U-shaped link with systolic pressure, peaking at 120.1 mmHg overall and 130.8 mmHg in prefrail older adults.