Pre-diabetes

2 papers9 findings

Human studies link higher BMI, age and apolipoprotein A1 to greater pre-diabetes risk, and HDL cholesterol to lower risk in multivariable analyses. A preprint links high-fibre foods to lower risk and larger waist circumference and frequent meat consumption to higher risk. A human study links pre-diabetes to more major adverse cardiovascular events after myocardial infarction.

Humans2

Interventions

1

Regular intake of high-fibre foods

downin humans1

1 study

Regular intake of high-fibre foods protect against pre-diabetes in humans.
Humans
Early screening of pre-diabetes in adults aged 40-69: a cross-sectional study
Research Square20 Sep 2026Preprint

More on Regular intake of high-fibre foods

Associations

8

Frequent meat consumption

upin humans1

1 study

Frequent meat consumption raises the risk of pre-diabetes in humans.
Humans
Early screening of pre-diabetes in adults aged 40-69: a cross-sectional study
Research Square20 Sep 2026Preprint

More on Frequent meat consumption

Large waist circumference

upin humans1

1 study

Large waist circumference raises the risk of pre-diabetes in humans.
Humans
Early screening of pre-diabetes in adults aged 40-69: a cross-sectional study
Research Square20 Sep 2026Preprint

Major adverse cardiovascular events

upin humans1HR 1.07

1 study

Pre-diabetes raise the risk of major adverse cardiovascular events in humans (HR 1.07, 95% CI 1.00 to 1.14).
Humanspost-myocardial infarction
Diabetes status, fasting glucose and HbA1c, and outcomes after myocardial infarction: a retrospective registry-based Swedish cohort study
BMJ open18 Sep 2026

Routine health examination data

upin humans1

1 study

routine health examination data predicts pre-diabetes in humans (AUC 0.806).
Humansbootstrap internal validation
Identification of multivariable predictors for prediabetes: biochemical integration and pathophysiological mechanism analysis based on health examination data
Frontiers in endocrinology5 Aug 2026

HDL cholesterol

downin humans1

1 study

HDL cholesterol lowers the risk of pre-diabetes in humans.
Humansmultivariable logistic regression
Identification of multivariable predictors for prediabetes: biochemical integration and pathophysiological mechanism analysis based on health examination data
Frontiers in endocrinology5 Aug 2026

More on HDL cholesterol

Apolipoprotein A1

upin humans1OR 2.736

1 study

Apolipoprotein A1 raises the risk of pre-diabetes in humans (OR 2.736, 95% CI 1.200-6.273).
Humansmultivariable logistic regression
Identification of multivariable predictors for prediabetes: biochemical integration and pathophysiological mechanism analysis based on health examination data
Frontiers in endocrinology5 Aug 2026

More on Apolipoprotein A1

Body mass index

upin humans1OR 1.12

1 study

Body mass index raises the risk of pre-diabetes in humans (OR 1.12, 95% CI 1.079-1.163).
Humansmultivariable logistic regression
Identification of multivariable predictors for prediabetes: biochemical integration and pathophysiological mechanism analysis based on health examination data
Frontiers in endocrinology5 Aug 2026

More on Body mass index

Age

upin humans1OR 1.105

1 study

Age raises the risk of pre-diabetes in humans (OR 1.105, 95% CI 1.093-1.117).
Humansmultivariable logistic regression
Identification of multivariable predictors for prediabetes: biochemical integration and pathophysiological mechanism analysis based on health examination data
Frontiers in endocrinology5 Aug 2026

Trial sponsors

Daiichi Sankyo
Company1 trialPhase 3502 people
Novartis
Company1 trialPhase 320 people
Vedic Lifesciences
Company1 trial104 people
Stanford University
3 trialsPhase 4239 people
Woman's
2 trialsPhase 4190 people
Mayo Clinic
2 trialsPhase 431 people
Seung-Whan Lee, M.D., Ph.D.
1 trialPhase 44,000 people
Ohio State University
1 trialPhase 4360 people

Funding

1 grant since 2023

Veterans Affairs

CSP #2002, Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes (VA-IMPACT)
Veterans AffairsVeterans Health Administration2023–2029

Latest

24 in 12 months

BMJ Open Diabetes Research & CareYesterday

Association between stress-related exposures and risk of pre-diabetes and type 2 diabetes: results from the population-based Lifelines cohort study

Cohort study of 152,861 peopleType 2 diabetes

medRxiv2 Oct

Prediction of Type 2 Diabetes using genomics and proteomics: the HUNT Study (ProtRS for T2D)

Preprint: cohort study of 3,221 peopleType 2 diabetes

Research Square21 Sep

Early screening of pre-diabetes in adults aged 40-69: a cross-sectional study

Preprint: cross-sectional study of 3,000 peoplePopulations

BMJ Open18 Sep

Diabetes status, fasting glucose and HbA1c, and outcomes after myocardial infarction: a retrospective registry-based Swedish cohort study

Cohort study of 47,558 peopleMyocardial infarction

Research Square12 Sep

TyGFI Predicts Depression in Pre-diabetes: A LightGBM and SHAP Analysis of CHARLS and NHANES

Preprint: cohort study of 1,887 peopleDepression

BMJ Open8 Sep

Optimised carbohydrate dietary intervention for improving metabolic health in adults with prediabetes: study protocol for a multicentre randomised controlled trial

Study protocolPrediabetes

BMJ Open Diabetes Research & Care3 Sep

Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women

Cross-sectional study of 7,735 peoplePopulations

bioRxiv25 Aug

N-glycome analysis of dried blood spots from different blood preparations and its potential for pre-diabetes and diabetes distinction

Preprint: cross-sectional study in peopleType 2 diabetes

Evolution, Medicine, and Public Health20 Aug

Physical activity and cardiometabolic health across an extreme lifestyle gradient

Cross-sectional study of 1,075 peopleCardiometabolic disease

Frontiers in Endocrinology20 Aug

Identification of multivariable predictors for prediabetes: biochemical integration and pathophysiological mechanism analysis based on health examination data

Cross-sectional study of 2,376 peopleBiomarkers