Panniculitis-associated lipoatrophy

1. PSMB8 induces panniculitis-associated lipoatrophy in mice.

   “as they aged, showed less weight gain and adipocyte shrinkage with interstitial macrophage infiltration and cytokine production/activation”

   Animalshomozygous founder variant G201V

   The homozygous founder Psmb8 variant of Nakajo-Nishimura syndrome/proteasome-associated autoinflammatory syndrome causes panniculitis-associated lipoatrophy and a shortened lifespan in mice

   Scientific reports·28 May 2026

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