There are 20 papers on osteopenia/osteoporosis in aging research: 19 observational studies in people, 1 review. The newest story, Oct 4, 2026: “Body composition shifts follow sex-specific paths across adulthood”.
20 papers study it147 more mention it26 findings
2 new papers in 30 daysSee all 167 papers on osteopenia/osteoporosis
“Higher SUA levels were significantly associated with a lower incidence of osteoporosis/osteopenia after adjustment for potential confounders and after subgroup analysis.”
Functional disability
no changein humans1OR 1.5
Osteopenia/osteoporosis was not clearly linked with functional disability in humans (OR 1.50, p = 0.185).
“Conversely, sarcopenia (OR: 1.50, p = 0.448) and osteopenia/osteoporosis (OR: 1.50, p = 0.185) phenotypes were not associated with functional disability.”
Humansn = 320
The journal of nutrition, health & aging
Coronary artery calcification
no changein humans1
Osteopenia/osteoporosis was not clearly linked with coronary artery calcification in humans (postmenopausal women).
“Osteopenia/osteoporosis was not significantly associated with CAC.”
Humanspostmenopausal womencoronary arteryfemalesn = 223
European review for medical and pharmacological sciences
CD57+ T-cell senescence
no changein humans1
CD57+ T-cell senescence was not clearly linked with osteopenia/osteoporosis in humans (cART-treated HIV-infected patients).
“When comparing the patients with osteopenia/osteoporosis with those with a normal BMD, no differences in activation and senescence were found.”
HumanscART-treated HIV-infected patientsmalesn = 16
The Netherlands journal of medicine
CD38+HLA-DR+ T-cell activation
no changein humans1
CD38+HLA-DR+ T-cell activation was not clearly linked with osteopenia/osteoporosis in humans (cART-treated HIV-infected patients).
“When comparing the patients with osteopenia/osteoporosis with those with a normal BMD, no differences in activation and senescence were found.”
HumanscART-treated HIV-infected patientsmalesn = 16
The Netherlands journal of medicine
Vertebral bone quality score
upin humans2
Osteopenia/osteoporosis is associated with vertebral bone quality score in humans (Osteopenia/osteoporosis versus normal bone mineral density) (3.37 ± 0.51 vs. 2.99 ± 0.44).
“Osteopenia/Osteoporosis patients exhibited significantly higher VBQ scores than normal bone mineral density patients (3.37 ± 0.51 vs. 2.99 ± 0.44, P<0.001).”
HumansOsteopenia/osteoporosis versus normal bone mineral densitylumbar spinen = 134
European journal of translational myology
Osteopenia/osteoporosis is associated with vertebral bone quality score in humans (osteoporosis or osteopenia compared with controls).
“The results showed a significantly higher VBQ score in the osteoporosis/osteopenia group compared with the control group.”
Reviewosteoporosis or osteopenia compared with controls
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Carbonated cola
upin humans1
Carbonated cola is associated with osteopenia/osteoporosis in humans (log odds ratio 1.017 (95% CI 0.876–1.158)).
“For osteoporosis/osteopenia, higher estimates were observed for carbonated cola [LOR = 1.017 (95% CI 0.876–1.158)]”
Review
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Epilepsy
upin humans1
Epilepsy is associated with osteopenia/osteoporosis in humans (chronic seizures and ≥ 10 years antiseizure medication exposure) (76.7% vs. 50.0%).
“Osteoporosis or osteopenia was found in 76.7% of cases versus 50.0% of controls ( p = 0.032).”
Humanschronic seizures and ≥ 10 years antiseizure medication exposuren = 60
Somatic Comorbidities in Older People Ageing with Epilepsy
International Journal of Epilepsy
Glucagon
upin humans1OR 1.112
Glucagon is linked with a higher risk of osteopenia/osteoporosis in humans (adjusted for age, BMI, diabetes duration, and antidiabetic therapies) (OR = 1.112, 95%CI:1.032-1.198, P = 0.006).
“elevated fasting glucagon was independently associated with a higher risk of osteopenia/osteoporosis (OR = 1.112, 95%CI:1.032-1.198, P = 0.006)”
Humansadjusted for age, BMI, diabetes duration, and antidiabetic therapiesn = 218
BMC endocrine disorders
Zinc
downin humans1OR 0.39
Zinc is associated with osteopenia/osteoporosis in humans (rheumatoid arthritis; adjusted for all covariates) (OR 0.39, 95% CI 0.18–0.86).
“higher dietary zinc intake was associated with lower odds of osteopenia or osteoporosis (OR = 0.39, 95%CI: 0.18-0.86) in RA patients.”
Humansrheumatoid arthritis; adjusted for all covariatesn = 905
BMC musculoskeletal disorders
Proton-pump inhibitors
upin humans1OR 2.91
Proton-pump inhibitors are associated with osteopenia/osteoporosis in humans (OR 2.91, 95% CI 1.692–4.979).
“The odds ratios (ORs) of diagnosis with PPI use was 2.91 (95% CI = [1.692, 4.979]) in osteoporosis/osteopenia.”
Humanslonger than 8 weeks
Effects of Prolonged Proton-Pump Inhibitor Use on Renal Dysfunction and Bone Fragility
The Annals of pharmacotherapy
Hyperlipidemia
upin humans1OR 2.61
Hyperlipidemia is linked with a higher risk of osteopenia/osteoporosis in humans (TC ≥ 240 mg/dL vs TC < 200 mg/dL) (OR 2.61; 95% CI, 1.44-4.71).
“Compared to people with total cholesterol (TC) < 200 mg/dL, those with TC ≥ 240 mg/dL tended to have osteopenia or osteoporosis (OR 2.61; 95% CI, 1.44-4.71).”
HumansTC ≥ 240 mg/dL vs TC < 200 mg/dL
Association of Decreased Bone Density and Hyperlipidemia in a Taiwanese Older Adult Population
Journal of the Endocrine Society
Mid-sagittal CT attenuation value
upin humans1+3.6% higher risk per one-unit reduction
Mid-sagittal CT attenuation value is associated with osteopenia/osteoporosis in humans (Per one-unit reduction in mid-sagittal CT attenuation value) (3.6% higher risk per one-unit reduction).
“For each one-unit reduction in mid-sagittal CT attenuation value, the risk of osteopenia or osteoporosis increased by 3.6%.”
HumansPer one-unit reduction in mid-sagittal CT attenuation value7th thoracic vertebra54% femalesn = 1,338
Clinical radiology
Dark-field signal
upin humans1
Dark-field signal predicts osteopenia/osteoporosis in humans (Cadaveric specimens imaged in vertical position) (AUC 0.80).
“For the differentiation between specimens with and without osteoporosis/osteopenia, the area under the ROC curve (AUC) was 0.80 for the dark-field signal in vertical position.”
HumansCadaveric specimens imaged in vertical positionlumbar vertebran = 58
Dark-field X-ray imaging for the assessment of osteoporosis in human lumbar spine specimens
Frontiers in physiology
Uric acid
downin humans1
Uric acid is associated with osteopenia/osteoporosis in humans.
“Higher SUA levels were significantly associated with a lower incidence of osteoporosis/osteopenia after adjustment for potential confounders and after subgroup analysis.”
Humansn = 19,881
Preprint
Company1 trialPhase 3110 people
Company1 trialPhase 2150 people
Seoul National University Bundang Hospital
1 trialPhase 470 people
1 trialPhase 433 people
1 trialPhase 340 people
1 trialPhase 2/390 people
1 trialPhase 2120 people
1 trialPhase 212 people
A cross-sectional study of 9,717 Caucasian adults aged 20 to 90 mapped age-related changes in bone, muscle, fat, and intramuscular adipose tissue.A cross-sectional study of 9,717 Caucasian adults aged 20 to 90 mapped age-related changes in bone, muscle, fat, and intramuscular adipose tissue.