Lower extremity fracture

1. Rapid kidney function decline is linked with a higher risk of lower extremity fracture in humans (HR 2.32 (95% CI, 1.15-4.71)).

   “lower-extremity, and major osteoporotic fractures were 2.18 (95 % CI, 1.24-3.85), 2.32 (1.15-4.71), and 2.91 (1.29-6.58), respectively”

   Humansmedian follow-up of 9.62 yearsn = 5,305

   Rapid decline of kidney function increases fracture risk in the general population: Insights from TLGS

   Bone·Nov 17, 2023

1. Obesity is linked with a higher risk of lower extremity fracture in humans (OR 1.25, 95% CI 1.12-1.38).

   “Obesity (odds ratio [OR] 1.25; 95% CI: 1.12-1.38) and dynapenia (OR 0.87; 95% CI: 0.77-0.98) were both independently associated with greater lower extremity fracture risk”

   Humansfemalesn = 16,147

   Reduced muscle strength (dynapenia) in women with obesity confers a greater risk of falls and fractures in the UK Biobank

   Obesity (Silver Spring, Md.)·Dec 11, 2022

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1. Body mass index is associated with lower extremity fracture in humans (BMI of 35-40 kg/m2) (aHR 2.43, 95% CI 1.92-3.06).

   “Higher BMI was associated to the increased risk for lower extremity fractures, especially ankle fractures, within five years of delivery.”

   HumansBMI of 35-40 kg/m2within five years after deliveryfemalesn = 529,992

   High BMI and the risk of lower extremity fractures in fertile-aged women: A nationwide register-based study in Finland

   Obesity research & clinical practice·Nov 26, 2022

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1. Statins are linked with a lower risk of lower extremity fracture in humans (observational studies) (RR 0.69, 95% CI 0.54-0.88).

   “lower extremity fracture (RR 0.69, 95% CI 0.54-0.88)”

   Humansobservational studies

   Effects of Statins on Relative Risk of Fractures for Older Adults: An Updated Systematic Review With Meta-Analysis

   Journal of the American Medical Directors Association·Aug 5, 2019

More on Statins