Leptin deficiency
1 paper1 finding
- Animals1
Interventions
1GD2TIF cells producing leptin
downin mice1
1 study
GD2TIF cells producing leptin
downin mice1
GD2TIF cells producing leptin decreases leptin deficiency in mice.
“In leptin-deficient ob/ob mice, a single infusion of GD2TIF cells producing leptin effectively and durably corrected leptin deficiency.”
Animalsin leptin-deficient ob/ob micesingle infusion
GD2TIF cells as a platform for single-dose and long-term delivery of biologics
Nature communications29 Aug 2025
Trial sponsors
1 trialPhase 2132 people
Latest
1 in 12 monthsNature Communications
GD2TIF cells as a platform for single-dose and long-term delivery of biologics
Experiments in miceInterventions
Biochimica et Biophysica Acta General Subjects
High glucose induces FABP3-mediated membrane rigidity via downregulation of SIRT1
Experiments in miceSirtuin signalling
bioRxiv
Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in liver of healthy and obese mice
Preprint: experiments in animalsMechanisms
Biochimica et Biophysica Acta General Subjects
Interplay between obesity and aging on myocardial geometry and function: Role of leptin-STAT3-stress signaling
Experiments in animalsMechanisms
Life Medicine
The natural product rotundic acid treats both aging and obesity by inhibiting PTP1B
Experiments in animalsInterventions
Frontiers in Physiology
Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient ob/ob mice
Experiments in animalsInterventions
GeroScience
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary
Experiments in 12 miceSenolytics
Cell Metabolism
Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling
Experiments in miceDietary restriction
Biochemical and Biophysical Research Communications
Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice
Experiments in miceMechanisms