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Isolated rapid eye movement sleep behavior disorder

There are 19 papers on isolated rapid eye movement sleep behavior disorder in aging research: 18 observational studies in people, 1 review. The newest story, Nov 8, 2026: “Two-step sleep disorder screen had no false positives in 54 controls”.

Disease

19 papers study it16 more mention it32 findings

1 new paper in 30 daysSee all 35 papers on isolated rapid eye movement sleep behavior disorder

“A derived threshold of serum L1EV α-synuclein distinguished participants with iRBD from controls (AUC = 0.91; 95% CI, 0.86-0.96)”
Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson DiseaseJAMA neurology2023doi:10.1001/jamaneurol.2023.4398
  • Humans18

Effects

7

Cognitive function

downin humans3

3 studies

  1. Isolated rapid eye movement sleep behavior disorder is linked with worse cognitive function in iRBD patients.

    “Motor and global cognitive functions exhibited nonlinear progression in iRBD, with marked acceleration before parkinsonism or dementia diagnosis.”

    Humansin iRBD patients6.9 yearsn = 133

    Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7-Year Prospective Matched Cohort Study

    Movement disorders : official journal of the Movement Disorder Society

  2. Isolated rapid eye movement sleep behavior disorder is linked with worse cognitive function in humans (p < 0.0003, effect size = 0.41).

    “iRBD participants (N = 197) demonstrated worse cognitive performance, including a lower cognitive summary score (p < 0.0003, effect size = 0.41)”

    Humans

    Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy

    Annals of clinical and translational neurology

  3. Isolated rapid eye movement sleep behavior disorder is linked with worse cognitive function in humans (at baseline compared to controls) (p = 0.037).

    “Patients with iRBD had lower scores on the Korean version of the Mini-Mental Status Examination (p = 0.037) and frontal and executive functions (p = 0.049) at baseline than those in controls”

    Humansat baseline compared to controls

    Static and dynamic brain morphological changes in isolated REM sleep behavior disorder compared to normal aging

    Frontiers in neuroscience

Amyotrophic lateral sclerosis

no changein silico1

1 study

  1. Isolated rapid eye movement sleep behavior disorder showed no clear effect on amyotrophic lateral sclerosis in silico (P > .05).

    “No significant causal relationship was identified between iRBD and amyotrophic lateral sclerosis (all P > .05).”

    In silico

    Refining the link between REM sleep behavior disorder and neurodegeneration: Genetic correlation, Mendelian randomization, and colocalization evidence

    Medicine

More on Amyotrophic lateral sclerosis

Perivascular space volume

upin humans1

1 study

  1. Isolated rapid eye movement sleep behavior disorder is linked with higher perivascular space volume in humans (compared to elderly controls).

    “Our results demonstrated increased CSF and PVS volumes in iRBD without a matching increase in drainage venous structures, as observed in elderly controls.”

    Humanscompared to elderly controlsbrain

    CSF turnover dysfunction: a hidden early biomarker in iRBD?

    NPJ Parkinson's disease

More on Perivascular space volume

Cerebrospinal fluid volume

upin humans1

1 study

  1. Isolated rapid eye movement sleep behavior disorder is linked with higher cerebrospinal fluid volume in humans (compared to elderly controls).

    “Our results demonstrated increased CSF and PVS volumes in iRBD without a matching increase in drainage venous structures, as observed in elderly controls.”

    Humanscompared to elderly controlsbrain

    CSF turnover dysfunction: a hidden early biomarker in iRBD?

    NPJ Parkinson's disease

More on Cerebrospinal fluid volume

Motor function

downin humans1

1 study

  1. Isolated rapid eye movement sleep behavior disorder is linked with worse motor function in iRBD patients.

    “Motor and global cognitive functions exhibited nonlinear progression in iRBD, with marked acceleration before parkinsonism or dementia diagnosis.”

    Humansin iRBD patients6.9 yearsn = 133

    Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7-Year Prospective Matched Cohort Study

    Movement disorders : official journal of the Movement Disorder Society

Constipation Assessment Scale Japanese version score

upin humans1

1 study

  1. Isolated rapid eye movement sleep behavior disorder is linked with higher Constipation Assessment Scale Japanese version score in humans (age- and gender-matched).

    “The CAS-J score was higher in the 22 IRBD patients than in 22 age- and gender-matched paired controls.”

    Humansage- and gender-matched

    Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

    Clinical parkinsonism & related disorders

More on Constipation Assessment Scale Japanese version score

Temporal muscle thickness

downin humans1

1 study

  1. Isolated rapid eye movement sleep behavior disorder is linked with lower temporal muscle thickness in humans (isolated rapid eye movement sleep behavior disorder) (11.843 vs. 10.420 mm, p = 0.002).

    “The TMT was reduced in patients with isolated RBD than in healthy controls (11.843 vs. 10.420 mm, p = 0.002).”

    Humansisolated rapid eye movement sleep behavior disorder

    Sarcopenia in patients with isolated rapid eye movement sleep behavior disorder

    Sleep medicine

More on Temporal muscle thickness

Associations

21

Wrist actigraphy

upin humans2

2 studies

  1. Wrist actigraphy predicts isolated rapid eye movement sleep behavior disorder in humans (isolated rapid-eye-movement sleep behavior disorder screening) (82% sensitivity and 84% specificity).

    “Actigraphy alone achieved 82% sensitivity and 84% specificity.”

    Humansisolated rapid-eye-movement sleep behavior disorder screeningn = 236

    Two-step sleep disorder screen had no false positives in 54 controls

    Annals of clinical and translational neurology

  2. Wrist actigraphy predicts isolated rapid eye movement sleep behavior disorder in humans (home wrist actigraphy >=14 nights) (82% sensitivity and 84% specificity).

    “Actigraphy alone achieved 82% sensitivity and 84% specificity.”

    Humanshome wrist actigraphy >=14 nightsn = 236

    A Two-Stage Questionnaire and Actigraphy Screening for Isolated REM Sleep Behavior Disorder in a Multicenter Cohort

    medRxivPreprint

More on Wrist actigraphy

Four-item questionnaire

upin humans2

2 studies

  1. four-item questionnaire predicts isolated rapid eye movement sleep behavior disorder in humans (isolated rapid-eye-movement sleep behavior disorder screening) (AUC 0.86).

    “The dream enactment question alone achieved an area under the curve of 0.85, which improved to 0.86 using the four-item questionnaire.”

    Humansisolated rapid-eye-movement sleep behavior disorder screeningn = 289

    Two-step sleep disorder screen had no false positives in 54 controls

    Annals of clinical and translational neurology

  2. four-item questionnaire predicts isolated rapid eye movement sleep behavior disorder in humans (multicenter cohort) (AUC 0.86).

    “The dream enactment question alone achieved an area under the curve of 0.85, which improved to 0.86 using the four-item questionnaire.”

    Humansmulticenter cohortn = 396

    A Two-Stage Questionnaire and Actigraphy Screening for Isolated REM Sleep Behavior Disorder in a Multicenter Cohort

    medRxivPreprint

Dementia with Lewy bodies

upin silico1OR 1.45

1 study

  1. Isolated rapid eye movement sleep behavior disorder raises the risk of dementia with Lewy bodies in silico (OR 1.45, 95% CI 1.03-2.06).

    “along with a causal association (OR = 1.45, 95% CI: 1.03-2.06, P = 3.53E-02), further supported by colocalization analysis”

    In silico

    Refining the link between REM sleep behavior disorder and neurodegeneration: Genetic correlation, Mendelian randomization, and colocalization evidence

    Medicine

More on Dementia with Lewy bodies

Multiple sclerosis

upin silico1OR 1.09

1 study

  1. Isolated rapid eye movement sleep behavior disorder raises the risk of multiple sclerosis in silico (OR 1.09, 95% CI 1.02-1.17).

    “multiple sclerosis (OR = 1.09, 95% CI: 1.02-1.17, P = 1.61E-02)”

    In silico

    Refining the link between REM sleep behavior disorder and neurodegeneration: Genetic correlation, Mendelian randomization, and colocalization evidence

    Medicine

More on Multiple sclerosis

Parkinson's disease

upin silico1OR 1.1

1 study

  1. Isolated rapid eye movement sleep behavior disorder raises the risk of Parkinson's disease in silico (OR 1.10, 95% CI 1.03-1.16).

    “Parkinson disease (OR = 1.10, 95% CI: 1.03-1.16, P = 2.96E-03)”

    In silico

    Refining the link between REM sleep behavior disorder and neurodegeneration: Genetic correlation, Mendelian randomization, and colocalization evidence

    Medicine

More on Parkinson's disease

Alzheimer's disease

upin silico1OR 1.02

1 study

  1. Isolated rapid eye movement sleep behavior disorder raises the risk of Alzheimer's disease in silico (OR 1.02, 95% CI 1.00-1.03).

    “iRBD demonstrated a positive causal association with Alzheimer disease (odds ratio [OR] = 1.02, 95% confidence interval [CI]: 1.00-1.03, P = 1.10E-02)”

    In silico

    Refining the link between REM sleep behavior disorder and neurodegeneration: Genetic correlation, Mendelian randomization, and colocalization evidence

    Medicine

More on Alzheimer's disease

Two-stage screening protocol (questionnaire followed by actigraphy)

upin humans1

1 study

  1. two-stage screening protocol (questionnaire followed by actigraphy) predicts isolated rapid eye movement sleep behavior disorder in humans (isolated rapid-eye-movement sleep behavior disorder screening) (73% sensitivity and 100% specificity).

    “the two-stage protocol-questionnaire followed by actigraphy-yielded 68% sensitivity and 100% specificity using the dream enactment question alone, and 73% sensitivity and 100% specificity using the four-item questionnaire.”

    Humansisolated rapid-eye-movement sleep behavior disorder screening

    Two-step sleep disorder screen had no false positives in 54 controls

    Annals of clinical and translational neurology

Neurodegenerative disease

upin humans1HR 9.6

1 study

  1. Isolated rapid eye movement sleep behavior disorder is linked with a higher risk of neurodegenerative disease in humans (vs non-RBD subjects) (HR 9.6, 95% CI 3.8-23.8, P < 0.001).

    “iRBD patients had a higher neurodegeneration risk (hazard ratio [95% confidence interval [CI]: 9.6 [3.8, 23.8], P < 0.001).”

    Humansvs non-RBD subjects6.9 years

    Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7-Year Prospective Matched Cohort Study

    Movement disorders : official journal of the Movement Disorder Society

More on Neurodegenerative disease

Autonomic symptoms

upin humans1OR 7.2

1 study

  1. Isolated rapid eye movement sleep behavior disorder is associated with autonomic symptoms in humans (OR = 7.2).

    “and neuropsychiatric (OR = 3.5), autonomic (OR = 7.2) and sensory symptoms (OR = 13.2)”

    Humans

    Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy

    Annals of clinical and translational neurology

Subthreshold parkinsonism

upin humans1OR 24.5

1 study

  1. Isolated rapid eye movement sleep behavior disorder is associated with subthreshold parkinsonism in humans (OR = 24.5).

    “higher odds of subthreshold parkinsonism (OR = 24.5)”

    Humans

    Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy

    Annals of clinical and translational neurology

More on Subthreshold parkinsonism

All 21

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 1May 2026: 2Jun 2026: 2Jul 2026: 3Aug 2026: 1Sep 2026: 0Oct 2026: 1Nov 2026: 112 papers in 12 months
Annals of Clinical and Translational Neurology

Two-step sleep disorder screen had no false positives in 54 controls

Four questions followed by wrist movement monitoring flagged 73% of confirmed cases and correctly classified 100% of controls among 129 participants.Four questions followed by wrist movement monitoring flagged 73% of confirmed cases and correctly classified 100% of controls among 129 participants.

Case-control · 129 peopleBiomarkers
Paper

See all 35 papers on isolated rapid eye movement sleep behavior disorder

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