Inner hair cell synaptopathy

1. Tauroursodeoxycholic acid protects against inner hair cell synaptopathy in mice.

   “TUDCA provided partial protection against IHC synaptopathy but did not prevent OHC loss.”

   AnimalsICR mice with accelerated age-related hearing losscochlealong-term

   Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss

   Neurobiology of aging·26 Aug 2025

More on Tauroursodeoxycholic acid

1. Mechanotransduction malfunction is associated with inner hair cell synaptopathy in mice.

   “we found that MET malfunction coexisted with synaptopathy in IHCs.”

   AnimalsC57BL/6J and ICR mouse strainsinner hair cell

   Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss

   Neurobiology of aging·26 Aug 2025

1. Inner hair cell synaptopathy is associated with outer hair cell loss in mice.

   “Regression analysis revealed a strong correlation between these variables across the high-to-low frequency axis of the cochlea.”

   AnimalsC57BL/6J and ICR mouse models of accelerated age-related hearing losscochlea

   Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss

   Neurobiology of aging·26 Aug 2025