Influenza infection
Disease1 paper1 finding
- Animals1
Interventions
1Amnesti-adjuvanted influenza vaccine
downin mice1Very low certainty
1 study
Amnesti-adjuvanted influenza vaccine
downin mice1Very low certainty
Amnesti-adjuvanted influenza vaccine protects against influenza infection in mice (complete protection).
Animalsin aged mice against representative influenza strainsmanganese-complexed liposome encapsulating STING agonist ADU-S100lungsingle dose
AMnESTI reverses age-associated lung immune decline to drive heterosubtypic protection by inactivated influenza vaccines · Science immunology · 11 Sep 2026
Trial sponsors
1 trialPhase 3640 people
Funding
National Institute on AgingUS$584.2k1 grant since 2020
Latest
3Mitochondrial TFAM limits CD8+ T cell lung damage in mice
In mice infected with influenza, CD8+ T cells lacking one TFAM copy provoked lung immunopathology without improving viral control and later lost…In mice infected with influenza, CD8+ T cells lacking one TFAM copy provoked lung immunopathology without improving viral control and later lost recall immunity.