male sex was not clearly linked with incident parkinsonism in humans (community-dwelling older adults without parkinsonism at baseline) (HR 1.06, 95% CI 0.91-1.23).
“Age (hazard ratio [HR] 1.09, 95% confidence interval [CI] 1.08-1.10) but not male sex (HR 1.06, 95% CI 0.91-1.23) was associated with incident parkinsonism.”
Humanscommunity-dwelling older adults without parkinsonism at baselineaverage 5 years of follow-upmalesn = 2,001
Multisystem vascular-related disease is associated with incident parkinsonism in humans (Any MVRD: sHR 1.35 (95% CI 1.23–1.48); each additional condition: sHR 1.30 (95% CI 1.21–1.40); one, two, and three or more conditions versus none: sHRs 1.29, 1.73, and 2.52).
“Any MVRD was associated with a higher risk of parkinsonism (sHR 1.35; 95% CI 1.23, 1.48)”
HumansWhite ethnicity; free of diagnosed parkinsonism at baseline; vascular parkinsonism excludedMedian follow-up of 11.8 yearsn = 456,862
Depressive symptoms, neuroticism, urinary incontinence, sleep complaints, and chronic health conditions
↑upin humans1
1 study
depressive symptoms, neuroticism, urinary incontinence, sleep complaints, and chronic health conditions are associated with incident parkinsonism in humans (community-dwelling older adults without parkinsonism at baseline).
“Depressive symptoms, neuroticism, urinary incontinence, sleep complaints, and chronic health conditions were associated with incident parkinsonism.”
Humanscommunity-dwelling older adults without parkinsonism at baselineaverage 5 years of follow-upn = 2,001
age is associated with incident parkinsonism in humans (community-dwelling older adults without parkinsonism at baseline) (HR 1.09, 95% CI 1.08-1.10).
“Age (hazard ratio [HR] 1.09, 95% confidence interval [CI] 1.08-1.10) but not male sex (HR 1.06, 95% CI 0.91-1.23) was associated with incident parkinsonism.”
Humanscommunity-dwelling older adults without parkinsonism at baselineaverage 5 years of follow-upn = 2,001
At least one of five specified vascular-related conditions was linked to higher parkinsonism risk than none, with a subdistribution hazard ratio, a relative risk measure…At least one of five specified vascular-related conditions was linked to higher parkinsonism risk than none, with a subdistribution hazard ratio, a relative risk measure, of 1.35.
A prospective cohort study of 374,751 UK Biobank participants linked higher levels of certain protein building blocks to a lower risk of developing Parkinson’s disease.A prospective cohort study of 374,751 UK Biobank participants linked higher levels of certain protein building blocks to a lower risk of developing Parkinson’s disease.
Irbesartan and olmesartan had hazard ratios of 0.588 and 0.797 for Parkinson’s disease; the abstract did not specify the comparison drugs.Irbesartan and olmesartan had hazard ratios of 0.588 and 0.797 for Parkinson’s disease; the abstract did not specify the comparison drugs.
For later Parkinson’s diagnosis, the hazard ratio—comparing rates over time—was 1.57 in people with depression and slowed movement and thinking versus those without…For later Parkinson’s diagnosis, the hazard ratio—comparing rates over time—was 1.57 in people with depression and slowed movement and thinking versus those without slowing.
Who was studied6,326 adults with depression, against people with depression without slowing
What changedParkinson's diagnosis rates were higher with slowed movement and thinking than without slowing among people with depression (hazard ratio 1.57)
The catchEarly Parkinson's disease could cause the slowing attributed to depression