High-grade serous ovarian cancer

1. Polygenic risk score raises the risk of high-grade serous ovarian cancer in humans (OR 1.40, P < 0.001).

   Humansper standard-deviation increase

   Using Polygenic Risk Scores to Refine Risk and Outcomes in High-grade Serous Ovarian Cancer in Australia

   Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·6 Aug 2026

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1. Drinking water contaminants mixture is associated with high-grade serous ovarian cancer in humans (HR 1.77, 95% CI 1.09-2.87).

   Humansper IQR increase in log2 concentrations of mixturefemales

   Exposures to Drinking Water Contaminants in Community Water Systems and Risk of Ovarian Cancer in the California Teachers Study Cohort

   Environmental health perspectives·20 May 2026

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1. Nitrate is associated with high-grade serous ovarian cancer in humans (HRperlog2 1.09, 95% CI 1.01-1.17).

   Humansper doubling in average concentrationsfemalesn = 59,881

   Exposures to Drinking Water Contaminants in Community Water Systems and Risk of Ovarian Cancer in the California Teachers Study Cohort

   Environmental health perspectives·20 May 2026

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