Aspirin
upin humans1HR 1.85
Aspirin raises the risk of hemorrhage in humans (HR 1.85, 95% CI 1.22-2.81).
“significantly increased the risk of extracranial hemorrhage requiring transfusion or hospitalization (0.86 [95% CI, 0.67-1.11] for aspirin vs 0.51 [95% CI, 0.37-0.72] for no aspirin; HR, 1.85 [95% CI, 1.22-2.81]; P = .004).”
Human trialatherosclerotic risk factorsenteric-coated100 mg/dmedian 5.02 yearsn = 14,464
JAMA17 Dec 2014
1 trialPhase 4447 people
Universitätsmedizin Greifswald
1 trialPhase 4270 people
University of Texas Southwestern Medical Center
1 trialPhase 443 people
1 trialPhase 360 people
University of Sao Paulo General Hospital
1 trialPhase 360 people
National Institute of Neurological Disorders and StrokeUS$11m
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
National Institute of Neurological Disorders and StrokeBeth Israel Deaconess Medical CenterUS$41.6k2021–2027
Sex- and age-dependent inflammation and vascular cognitive impairment after intracerebral hemorrhage
National Institute of Neurological Disorders and StrokeYale UniversityUS$1.3m2026–2028
StATins Use in intRacerebral hemorrhage patieNts (SATURN)
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Proteomics and Cognitive Decline Following Intracerebral Hemorrhage
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National Institute of Neurological Disorders and StrokeMassachusetts General HospitalUS$776.5k2023–2025
Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.
In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.
In 12-month-old Col4a2 mutant mice, cerebral pial arteries showed impaired myogenic tone driven by PKA-dependent remodeling of ryanodine receptor clusters.In 12-month-old Col4a2 mutant mice, cerebral pial arteries showed impaired myogenic tone driven by PKA-dependent remodeling of ryanodine receptor clusters.