Gastric adenoma

1. STAT3 increases gastric adenoma in mice.

   “suppressed the growth of spontaneously arising gastric adenomas in young mice”

   Animalsin gp130(Y757F/Y757F) mice

   Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

   Nature medicine·24 Jul 2005

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